Macroporous silicon-wollastonite scaffold with Sr/Se/Zn/Mg-substituted hydroxyapatite/chitosan hydrogel

The scaffolds, which morphologically and physiologically mimic natural features of the bone, are a high demand for regenerative medicine. To address this challenge, bioactive porous silicon/wollastonite (SC) scaffold has been developed potential bone tissue engineering applications. Additive manufacturing through selective laser melting approach exploited to fabricate computer-aided designed scaffolds with pore size 400 ?m. increase biocompatibility osteogenic properties SC hydrogel based on mixture four mono-substituted hydroxyapatites (sHAp) biopolymer chitosan (CHT) incorporated into by impregnation freeze-gelation method. ?m provided enough space polymer solution composite (CHT/sHAp) suspension form highly within pores. By combination CHT/sHAp, both cell attachment homogeneous proliferation as well mechanical CHT/sHAp have improved.